Table 3.

Barriers to clinical trial

			Mistrust in the Medical And Scientific Community	Safely and Efficacy of Procedure or Medicati on	Fear of Experimentation or Randomization	Limited understanding/access to info about clinical trials	Time Commitment and/or location concerns	Patient- Researcher Relationship	Financial burden (i.e. inadequate insurance, no compensati on, lack of research funding)	Caregiving Duties	Inadequate Transport	Limited understanding of the informed consent process	Reputation of Medical Professional or Facility	Work Commitment	Unequa l Treatment	Religious Beliefs	Physical Discomfort	Lack of Interest	Unexpected Event (e.g., illness, incarnation, or oversleeping
Author/Year	Sample Size	Sex
Baquet, C. et al., 2006	561	Female								x	x
BeLue, R et al., 2006	35	Female			x			x							x
	32	Male	x		x				x			x	x
Brewer, L. et al., 2014	381	Female		x
Brooks, M.M. et al., 2009	29	Female	x		x	x		x	x				x		x	x
Brown, D. et al., 2000				x						x	x
Study 1	64	Female
Brown, D. et al., 2000						x		x		x
Study 2	61	Female
Farmer, D. et al., 2007	61	Female	x	x	x		x			x		x		x	x		x
Frierson, G. et al., 2019	57	Female	x		x	x	x	x	x		x
Haynes-Maslow, L. et al., 2014	82	Female	x			x		x	x		x					x
Lang, R. et al., 2013	69	Female	x				x						x					x
	35	Male	x				x
Linden, H. et al., 2007	58	Female	x	x	x	x	x		x	x	x			x		x
Martin, A et al., 2013	36	Female					x						x					x
Newman, P. et al., 2006	8	Female		x
Owens, O. et al., 2013	43	Female	x	x	x	x	x			x		x		x
	38	Male	x	x	x	x	x			x		x		x
Rivers, D. et al., 2019	42	Female	x	x	x	x			x				x
Smith, Y. et al., 2007	31	Female	x			x	x	x	x	x				x
Trauth, J. et al., 2005	299	Female	x	x	x	x		x				x
Unson, C. et al., 2001	16	Female	x	x	x			x			x				x
Voytek, C. et al., 2011	17	Female	x	x	x		x		x	x		x					x		x

NOTE: This table lists each study included in the systematic review and whether the specific barrier to participation in clinical trials was identified by the study’s male and/or female subjects.