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(A) Proposed model for heterochromatin-mediated silencing of α-satellite DNA regions by BRCA1/BARD1-dependent H2A-Ub. (B) Proposed model for regulation of estrogen metabolism through modulation of CYP450 expression levels in breast epithelial cells (MCF10a) by BRCA1/BARD1-dependent H2A-Ub.
