Table 5.
Adverse events of lenvatinib monotherapy (n = 90).
| AEs∗ | Not happened | Grade 1 | Grade 2 | Grade 3 | Grade 4 | happened | Any grade |
|---|---|---|---|---|---|---|---|
| hypertension | 56 (62.22) | 18 | 12 | 4 | 0 | 34 (37.78) | 4 (4.44) |
| HFSR | 73 (81.11) | 11 | 5 | 1 | 0 | 17 (18.89) | 1 (1.11) |
| Asthenia | 60 (66.67) | 17 | 13 | 0 | 0 | 30 (33.33) | 0 (0.00) |
| diarrhoea | 66 (73.33) | 11 | 12 | 1 | 0 | 24 (26.67) | 1 (1.11) |
| Constipation | 77 (85.56) | 10 | 3 | 0 | 0 | 13 (14.44) | 0 (0.00) |
| Abdominal pain | 69 (76.67) | 15 | 6 | 0 | 0 | 21 (23.33) | 0 (0.00) |
| Bloating | 72 (80.00) | 11 | 7 | 0 | 0 | 18 (20.00) | 0 (0.00) |
| Nausea | 69 (76.67) | 17 | 4 | 0 | 0 | 21 (23.33) | 0 (0.00) |
| Vomiting | 75 (83.33) | 8 | 7 | 0 | 0 | 15 (16.67) | 0 (0.00) |
| Loss of appetite | 68 (75.56) | 14 | 8 | 0 | 0 | 22 (24.44) | 0 (0.00) |
| OM | 85 (94.44) | 5 | 0 | 0 | 0 | 5 (5.56) | 0 (0.00) |
| Joint pain | 74 (82.22) | 15 | 1 | 0 | 0 | 16 (17.78) | 0 (0.00) |
| peripheral edema | 82 (91.11) | 8 | 0 | 0 | 0 | 8 (8.89) | 0 (0.00) |
| Proteinuria | 67 (74.44) | 18 | 5 | 0 | 0 | 23 (25.56) | 0 (0.00) |
| Leukopenia | 80 (88.89) | 7 | 2 | 1 | 0 | 10 (11.11) | 1 (1.11) |
| Thrombocytopenia | 83 (92.22) | 6 | 1 | 0 | 0 | 7 (7.78) | 0 (0.00) |
Data are presented as n (%); ∗ counting overlapping; oral mucositis (OM); hand-foot skin reaction (HFSR).