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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Curr Opin Struct Biol. 2022 Apr 7;74:102369. doi: 10.1016/j.sbi.2022.102369

Figure 3. Mechanism of ACAT-mediated cholesterol esterification.

Figure 3.

(a) Overall structure of the ACAT1 tetramer (pdb: 6VUM). Cholesterol (yellow), acyl-CoA (grey), and nevanimibe (light pink) are shown as sticks. (b) Working model of ACAT enzymes, showing the catalytic histidine, cholesterol, and acyl-CoA.