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. Author manuscript; available in PMC: 2022 Oct 8.
Published in final edited form as: Nat Methods. 2022 Apr 8;19(6):711–723. doi: 10.1038/s41592-022-01475-6

Figure 1. Genome-wide mapping of protein-DNA interactions with DiMeLo-seq.

Figure 1.

a, Schematic of the DiMeLo-seq workflow for mapping protein-DNA interactions b-f DiMeLo-seq can be used to map multiple interaction sites for a protein of interest on each chromatin fiber (b), estimate protein-DNA interaction frequencies (c), study the joint relationship between endogenous DNA methylation and protein binding (d), study genetic or epigenetic effects on protein binding between parental haplotypes (e), map protein-DNA interactions across repetitive regions (f).