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Designing Pis-1 analogs. a, Pis-1. Residues 1–18 are plotted on a helical wheel. The four histidines are at the hydrophilic-hydrophobic interface (blue circles). b, Pis-KR. Lysine and arginine (red circles) are placed at the hydrophilic-hydrophobic interface. c, Pis-mH. Lysine and arginine (red circles) are placed at the hydrophilic-hydrophobic interface, and histidines (blue circles) are placed in the middle of the hydrophilic face.
