Table2.
Incidence and outcome of severe DILD caused by antineoplastic drugs
| Number of patients | Number of drugs | Severe DILD with hospitalization | Imaging pattern of DILD | Successful steroid withdrawal | Number of treatment-related death in severe DILD | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | |||||
| Total | 19,132 | 56,651 | 120 | 0.62 | 31 | 25.83 | 22 | 18.33 | ||
| Cytotoxic agents | 17,251 | 51,083 | 76 | 0.44 | HP | 34 | 23 | 30.26 | 16 | 21.05 |
| DAD | 13 | |||||||||
| OP | 12 | |||||||||
| other | 17 | |||||||||
| Molecular targeted agents | 3989 | 5385 | 21 | 0.52 | HP | 5 | 6 | 28.57 | 2 | 9.52 |
| DAD | 1 | |||||||||
| OP | 12 | |||||||||
| Other | 2 | |||||||||
| no CT | 1 | |||||||||
| Immune-checkpoint inhibitors | 975 | 1165 | 23 | 2.35 | HP | 8 | 3 | 13.04 | 4 | 17.39 |
| DAD | 1 | |||||||||
| OP | 11 | |||||||||
| Other | 2 | |||||||||
| no CT | 1 | |||||||||