Figure 1.

Iloprost requires Fzd₉ to prevent murine adenoma development

(A) Schematic of urethane and inhaled iloprost lung cancer chemoprevention model.

(B) Change in weights of mice in the urethane and inhaled iloprost model.

(C) Average adenoma number per mouse in the urethane exposed groups.

(D) Diameter of adenomas in urethane exposed groups.

(E) Average number of Ki67 expressing cells/mm² adenoma area per mouse exposed to urethane. Urethane mice are compared to their genotype saline control.

(F) microCT image of Fzd₉^−/− urethane iloprost mouse lung.

(G) H&E of a representative adenoma generated by the 15-week urethane model. WUS, wild type urethane saline; WUI, wild type urethane iloprost; FUS, Fzd₉^−/− urethane saline; FUI, Fzd₉^−/− urethane iloprost. Data are represented as mean ± SEM. One-way ANOVA with Tukey’s post hoc test was used to measure significance. ∗p < 0.05. Scale bar is 100uM.