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. 2022 Mar 20;6(6):2100094. doi: 10.1002/gch2.202100094

Figure 3.

Figure 3

Inducers and intracellular pathways involved in stiffness‐mediated EMT in different types of cancers. The mechanotransduction pathways in different types of cancers are not the same. In most cases, a stiff ECM can promote EMT in cancer cells, while in H‐Ras‐transformed MCF10A cells and metastatic OCCs, it is a soft matrix that promotes EMT.