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. 2022 Jun 13;185(14):2452–2468.e16. doi: 10.1016/j.cell.2022.06.008

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© 2022 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Figure S1 — SARS-CoV-2 mouse models, related to Figure 1

(A) Neuroinvasive SARS-CoV-2 mouse model as a positive control for detection of virus in the brain. Confocal micrograph of coronal section of mouse brain, illustrating SARS-CoV-2 nucleocapsid protein (SARS-CoV-2-N) 7 days post-infection (7DPI) (SARS-CoV-2-N, magenta; DAPI, cyan). Scale bars, 1 mm.

(B) Mild respiratory COVID mouse model, detection of virus in the lung. Representative confocal micrographs of SARS-CoV-2 nucleocapsid protein (SARS-CoV-2-N, magenta; DAPI, cyan) in mouse lung 7 days post-infection, a time point at which the viral infection is largely cleared. Arrowheads highlight SARS-CoV-2-N nucleocapsid protein immunostaining (magenta). Scale bars, 100 μm.

(C) Mild respiratory COVID mouse model, hematoxylin and eosin (H&E) histology in mouse lung tissue at 7 days and 7 weeks post-mild respiratory SARS-CoV-2 infection (7WPI). Minimal interstitial infiltrates with patchy lymphoid aggregates were observed without evidence of alveolar damage. Scale bars, 200 μm.