Histological and immunohistochemical analysis of microgels after 4 and 12 weeks implantation in mandibular bone defects. (A) HE staining images of the defect region at week 4 and 12 pos-timplantation (Scale bars: 500 μm, white rectangle: the lateral margin and the center region of the defects). (B–E) HE staining, Masson's trichrome staining, OCN staining, and COL-1 staining images of lateral margin and center region of the defect region (Scale bars: 100 μm, ∗: new bone, &: microgels).