Table 1.
Major metabolic pathways in innate cells
| Cell type | Energy sources in quiescent state | Energy sources in activition state | Related pathway changes | References |
|---|---|---|---|---|
| DCs | TCA cycle, OXPHOS |
Glycolysis, lactic fermentation |
TBK1-IKKε/AKT/HK-II pathway,PI3K/AKT/mTOR pathway,mTOR/HIF1α/iNOS pathway | [13, 15, 17, 18] |
| Macrophage | TCA cycle, OXPHOS |
M1: aerobic glycolysis, FAO M2: FAO, gluconeogenesis |
HIF-1a/PDK1 pathway, Akt/mTORC1 pathway, JAK/STAT6 Pathway, PPARγ/LXR/ABCA1 pathway | [32, 33, 36, 38] |
| NK cells | TCA cycle, OXPHOS, glutaminolysis |
OXPHOS, aerobic glycolysis |
PI3K/Akt/mTORC1 pathway, JAK/STAT pathways,NF-kB pathways |
[44, 46–48] |