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. 2022 May 30;10:800574. doi: 10.3389/fcell.2022.800574

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Copyright © 2022 Chung, Lee, Hyun, Kim, Cho, Lee, Kang, Chung and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Curcumin reduces high glucose-induced CCL2 and VEGF expression in renal podocytes. Supernatant CCL2 was measured by ELISA (A,C), and podocyte CCL2 mRNA was measured by real-time PCR (B). High glucose-induced CCL2 protein (A) and mRNA expression (B) were markedly improved after curcumin treatment. Podocytes treated with 10 ng/ml of TNF-α for 24 h increased the CCL2 protein expression. Curcumin treatment significantly reduced TNF-α-induced CCL2 protein in the podocytes (C). High glucose-induced VEGF mRNA expression was significantly reduced by curcumin (D). Vascular endothelial growth factor, VEGF; C-C motif chemokine ligand 2, CCL2; NG, normal glucose; HG, high glucose. *, p < 0.05 versus NG; **, p < 0.001 versus NG; +, p < 0.05 versus HG or TNF-α.