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. 2022 May 30;10:800574. doi: 10.3389/fcell.2022.800574

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Copyright © 2022 Chung, Lee, Hyun, Kim, Cho, Lee, Kang, Chung and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Curcumin works as an inhibitor of RIPK3 to protect renal podocytes and MES-13 cells from high glucose-induced injury. High glucose-induced RIPK3 overexpression in podocytes was significantly reduced by curcumin treatment (A). Representative immunoblot for RIPK3, pRIPK3, and pMLKL by Western blot in mouse mesangial (MES-13) cells treated with high glucose with or without 1 μM of curcumin and 1 μM of DHZ for 24 h (B). NG, normal glucose; HG, high glucose. *, p < 0.05 versus NG; +, p < 0.05 versus HG.