Table 6. Crude mortality rates and hazard ratios for ASCVD mortality according to non-fasting triglyceride category stratified by age <65 and ≥65 years.
| Baseline non-fasting triglyceride level | |||||||
| ≤59 mg/dL | 60–89 mg/dL | 90–119 mg/dL | 120–149 mg/dL | 150–179 mg/dL | 180–209 mg/dL | ≥210 mg/dL | |
| ASCVD death | |||||||
| Age <65 years | |||||||
| Men | |||||||
| Number of participants | 176 | 432 | 468 | 311 | 249 | 172 | 430 |
| Person-years | 3,238 | 8,080 | 8,824 | 5,864 | 4,671 | 3,239 | 8,085 |
| Number of deaths | 4 | 6 | 10 | 5 | 2 | 1 | 9 |
| Crude mortality rate | 1.2 | 0.7 | 1.1 | 0.9 | 0.4 | 0.3 | 1.1 |
| Hazard ratio (95% CI) | |||||||
| Model 1 | 2.64 (0.48–14.41) | 1.57 (0.31–7.79) | 2.29 (0.50–10.48) | 1.97 (0.38–10.17) | Ref. | 0.77 (0.07–8.53) | 2.77 (0.59–12.82) |
| Model 2 | 2.33 (0.38–14.15) | 1.66 (0.32–8.58) | 2.09 (0.44–9.84) | 1.72 (0.33–9.02) | Ref. | 0.68 (0.06–7.60) | 2.22 (0.46–10.61) |
| Model 3 | 2.54 (0.38–16.93) | 1.76 (0.32–9.47) | 2.18 (0.45–10.47) | 1.76 (0.33–9.26) | Ref. | 0.68 (0.06–7.66) | 2.17 (0.45–10.45) |
| Women | |||||||
| Number of participants | 571 | 888 | 634 | 434 | 241 | 145 | 269 |
| Person-years | 11,176 | 17,310 | 12,287 | 8,386 | 4,657 | 2,770 | 5,180 |
| Number of deaths | 0 | 4 | 4 | 1 | 2 | 1 | 2 |
| Crude mortality rate | 0 | 0.2 | 0.3 | 0.1 | 0.4 | 0.4 | 0.4 |
| Hazard ratio (95% CI) | |||||||
| Model 1 | — | 0.92 | 1.01 | 0.28 | Ref. | 0.83 | 0.85 |
| — | (0.16–5.11) | (0.18–5.55) | (0.02–3.11) | (0.07–9.23) | (0.12–6.06) | ||
| Model 2 | — | 0.89 | 0.93 | 0.31 | Ref. | 0.97 | 0.93 |
| — | (0.14–5.45) | (0.16–5.32) | (0.02–3.55) | (0.08–10.87) | (0.12–6.84) | ||
| Model 3 | — | 2.06 | 1.60 | 0.44 | Ref. | 0.93 | 0.62 |
| — | (0.28–14.80) | (0.26–9.71) | (0.03–5.15) | (0.08–10.50) | (0.08–4.61) | ||
| Total | |||||||
| Number of participants | 747 | 1,320 | 1,102 | 745 | 490 | 317 | 699 |
| Person-years | 14,414 | 25,390 | 21,111 | 14,250 | 9,328 | 6,009 | 13,265 |
| Number of deaths | 4 | 10 | 14 | 6 | 4 | 2 | 11 |
| Crude mortality rate | 0.3 | 0.4 | 0.7 | 0.4 | 0.4 | 0.3 | 0.8 |
| Hazard ratio (95% CI) | |||||||
| Model 1 | 1.19 (0.29–4.76) | 1.26 (0.39–4.02) | 1.64 (0.54–5.00) | 1.07 (0.30–3.79) | Ref. | 0.79 (0.14–4.32) | 1.83 (0.58–5.77) |
| Model 2 | 1.04 (0.24–4.48) | 1.32 (0.39–4.37) | 1.51 (0.48–4.69) | 0.93 (0.26–3.35) | Ref. | 0.67 (0.12–3.70) | 1.58 (0.49–5.12) |
| Model 3 | 1.49 (0.32–6.94) | 1.68 (0.48–5.83) | 1.76 (0.55–5.59) | 1.03 (0.28–3.73) | Ref. | 0.68 (0.12–3.76) | 1.41 (0.43–4.62) |
| Age ≥65 years | |||||||
| Men | |||||||
| Number of participants | 78 | 155 | 127 | 87 | 46 | 41 | 81 |
| Person-years | 855 | 1,847 | 1,588 | 1,169 | 655 | 507 | 1,128 |
| Number of deaths | 10 | 20 | 13 | 7 | 3 | 6 | 9 |
| Crude mortality rate | 11.7 | 10.8 | 8.2 | 6.0 | 4.6 | 11.8 | 8.0 |
| Hazard ratio (95% CI) | |||||||
| Model 1 | 2.40 (0.65–8.75) | 1.99 (0.58–6.73) | 1.60 (0.45–5.64) | 1.20 (0.31–4.65) | Ref. | 2.17 (0.54–8.72) | 1.61 (0.43–5.95) |
| Model 2 | 4.11 (1.06–15.87) | 2.92 (0.82–10.31) | 1.96 (0.54–7.03) | 1.26 (0.32–4.94) | Ref. | 1.92 (0.47–7.79) | 1.46 (0.38–5.52) |
| Model 3 | 5.20 (1.29–20.90) | 3.57 (0.98–12.96) | 2.24 (0.61–8.16) | 1.38 (0.35–5.41) | Ref. | 1.92 (0.47–7.76) | 1.34 (0.35–5.11) |
| Women | |||||||
| Number of participants | 53 | 166 | 198 | 116 | 95 | 65 | 103 |
| Person-years | 634 | 2,336 | 2,793 | 1,720 | 1,444 | 1,074 | 1,667 |
| Number of deaths | 8 | 17 | 15 | 13 | 7 | 5 | 11 |
| Crude mortality rate | 12.6 | 7.3 | 5.4 | 7.6 | 4.8 | 4.7 | 6.6 |
| Hazard ratio (95% CI) | |||||||
| Model 1 | 2.50 (0.90–6.93) | 1.38 (0.57–3.35) | 1.12 (0.45–2.76) | 1.56 (0.62–3.92) | Ref. | 0.96 (0.30–3.04) | 1.45 (0.56–3.76) |
| Model 2 | 2.04 (0.69–5.99) | 1.25 (0.51–3.09) | 1.05 (0.42–2.63) | 1.49 (0.59–2.43) | Ref. | 0.93 (0.29–2.96) | 1.51 (0.58–3.92) |
| Model 3 | 1.83 (0.60–5.53) | 1.12 (0.44–2.87) | 1.00 (0.39–2.51) | 1.47 (0.58–3.72) | Ref. | 0.95 (0.30–3.05) | 1.67 (0.62–4.46) |
| Total | |||||||
| Number of participants | 131 | 321 | 325 | 203 | 141 | 106 | 184 |
| Person-years | 1,488 | 4,182 | 4,381 | 2,889 | 2,099 | 1,581 | 2,794 |
| Number of deaths | 18 | 37 | 28 | 20 | 10 | 11 | 20 |
| Crude mortality rate | 12.1 | 8.8 | 6.4 | 6.9 | 4.8 | 7.0 | 7.2 |
| Hazard ratio (95% CI) | |||||||
| Model 1 | 2.33 (1.06–5.08) | 1.60 (0.79–3.24) | 1.30 (0.63–2.68) | 1.37 (0.64–2.95) | Ref. | 1.36 (0.58–3.22) | 1.48 (0.69–3.18) |
| Model 2 | 2.57 (1.13–5.86) | 1.70 (0.82–3.51) | 1.35 (0.65–2.82) | 1.43 (0.66–3.08) | Ref. | 1.33 (0.56–3.14) | 1.49 (0.69–3.21) |
| Model 3 | 2.66 (1.15–6.18) | 1.76 (0.83–3.69) | 1.38 (0.65–2.90) | 1.44 (0.67–3.12) | Ref. | 1.32 (0.56–3.13) | 1.46 (0.67–3.17) |
CI, confidence interval; ASCVD, atherosclerotic cardiovascular disease.
Model 1 was adjusted for age.
Model 2 was adjusted for variables in model 1 plus body mass index, total cholesterol, hypertension, diabetes, smoking status, and alcohol drinking status.
Model 3 was adjusted for variables in model 2 plus high-density lipoprotein cholesterol.
The model for total participants (in which the sexes were combined) was also adjusted for sex.
Crude mortality rate is shown as per 1,000 person-years.