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. 2022 May 30;12:848346. doi: 10.3389/fonc.2022.848346

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Copyright © 2022 Zhang, Waheed, Armato, Wu, Zhang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The protein-protein interaction clustering of differentially expressed genes while eIF6 was up-regulated in cancers. The significantly up-regulated genes in the eIF6 altered group were clustered according to protein interactions. The ribosomal proteins formed clusters in all five cancers. The cytoskeletal proteins were clustered in SKCM, LUAD, and PAAD, while the cell-cycle and metabolism proteins were clustered in PAAD and LUAD and LIHC cancers, respectively.