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. 2022 May 30;9:783592. doi: 10.3389/fmed.2022.783592

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Copyright © 2022 Peng, Yang, Song, Wang and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CAPN2 expression regulates the migration and invasion of PC cells in vitro. (A,B) The migratory abilities of siRNA1,2-transfected Panc-1 cells and SW1990 cells were detected by a wound healing assay. Representative images and the quantitative analysis of the distance between wound edges at 6, 12, and 24 h. (C,D) Cell migratory abilities were detected by the Transwell migration assay. Quantitative analysis and representative images of the number of migrating cells in siRNA#2-transfected Panc-1 cells and control cells. (E) Western blot analysis shows that MMP9 and MMP2 protein levels were significantly reduced in CAPN2-silenced Panc-1 cells and SW1990 cells compared with that in control cells. *P < 0.05.