Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 12;12(6):e894. doi: 10.1002/ctm2.894

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Schematic illustration describing the underlying mechanism of Toll‐like receptor 4 (TLR4)‐mediated microglial pyroptosis after spinal cord injury (SCI). After injury, overexpressed TLR4 recognises danger‐associated molecular patterns (DAMPs) and interacts with biglycan (BGN) to activate the JAK2/STAT1 pathway. Furthermore, STAT1, as a transcriptional activator, upregulates the expression of dead‐box helicase 3 X‐linked (DDX3X) and subsequently aggravates NLR family pyrin domain containing 3 (NLRP3) inflammasome activation and microglial pyroptosis. This figure was drawn with Biorender (www.biorender.com)