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. 2022 Jun 13;377(1856):20210207. doi: 10.1098/rstb.2021.0207

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© 2022 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — Two mechanisms by which segmental duplications can lead to recombination suppression. (a) Ectopic recombination between mis-paired paralogues in different parts of the chromosome can cause an inversion of the intervening region. This mechanism is most relevant when the paralogues are ‘young’ and still share strong sequence similarity. (b) Our proposed model of duplication, divergence and differential loss. Over long periods of time, old paralogues may become highly diverged in their sequences. If differential loss of paralogues occurs in different individuals, the remaining copies may be too divergent to pair up and crossover during meiosis. (Online version in colour.)