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. 2022 Apr 11;9(17):2200079. doi: 10.1002/advs.202200079

Figure 5.

Figure 5

Cellular and molecular mechanisms of ST‐needle therapy for OA. A) Diagram of ST‐needles inhibiting cytokine synthesis and promoting stem cell migration. B) X‐rays showed that the ST‐needles accurately reached the subchondral bone. C) The Western blot of 15‐LOX‐1 and TGF‐β1. D–E) Quantitative analysis of the Western blot results of 15‐LOX‐1 and TGF‐β1. F,G) The PCR of mRNA of 15‐LOX‐1 and TGF‐β1. H) Schematic diagram of the experiment, in which the ST‐needle promoted MSC migration. I) Representative fluorescence images show live staining of the MSCs migrating through the cartilage. J) Quantitative analysis of live cells (n = 3). (* P < 0.05, ** P < 0.01, *** P < 0.001).