Figure 6.

The mechanism of LCA/LGG‐LDB mediated hepatoxicity remission in VPA‐induced cholestasis. Total BAs in A) liver, B) serum, and C) feces. Relative mRNA level of D) Fxr and E) Shp in ileum. The concentration of FGF‐15 in F) ileum and G) serum. Relative mRNA level of H) Cyp7a1, I) Shp, and J) Bsep in liver. K) BSH content in feces. The data were presented as the mean ± s.d., n = ≈3–5. The statistical significance was calculated via one‐way ANOVA with Tukey's multiple comparisons test. *P < 0.05, **P < 0.01, ***P < 0.001.