Table 2.
Diagnostic performance of age specific thresholds of N-terminal pro-B-type natriuretic peptide (NT-proBNP) for acute heart failure
| Age groups | NT-proBNP threshold (pg/mL) | True positive | False positive | True negative | False negative | Prevalence of acute heart failure (%) | NPV (95% CI) | PPV (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| <50 years | 450 | 203 | 130 | 1025 | 19 | 16.1 | 98.4 (96.2 to 99.3) | 61.0 (55.3 to 66.4) | 91.4 (87.0 to 94.5) | 87.8 (79.5 to 93.0) |
| 50-75 years | 900 | 1407 | 575 | 2121 | 267 | 38.3 | 88.3 (82.9 to 92.2) | 73.5 (62.3 to 82.3) | 83.2 (76.0 to 88.6) | 81.1 (72.6 to 87.5) |
| >75 years | 1800 | 2135 | 621 | 1348 | 518 | 57.4 | 72.2 (63.4 to 79.7) | 80.2 (70.9 to 87.1) | 79.3 (74.2 to 83.5) | 73.1 (65.2 to 79.8) |
| All | 300 | 4388 | 2833 | 2987 | 161 | 43.9 | 94.6 (91.9 to 96.4) | 62.9 (51.3 to 73.3) | 96.8 (94.6 to 98.1) | 49.3 (35.4 to 63.4) |
CI=confidence interval; NPV=negative predictive value; PPV=positive predictive value.