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Filaggrin expression and processing in the epidermis. The pro-protein profilaggrin is cleaved in a stepwise process into filaggrin monomers which are then degraded to release amino acids, contributing to ‘natural moisturising factors’ in the stratum corneum (19, 20). Filaggrin is an important marker of keratinocyte differentiation. SC: stratum corneum; SG: stratumgranulosum; SS: stratumspinosum; SB: stratum basale.
