Table I.

Summary of potential melanoma predictive biomarkers

Tumour	Host	Microenvironment
Tumour mutation burden and neoantigen expression	CD8 T cells	Microbiome
Driver mutations	T-cell receptor	Immunosuppressive stroma/immune cell
Aberrant signaling pathways (including WNT/bcatenin, JAK1/2, VEGF)	Immunoscore	environment including TGFb pathway
MHC	Neutrophil:lymphocyte ratio	PD-L1 expression
B2Microglobulin	Cytokines eg. IL17
PD-L1 expression	Immune-related gene expression profiles
Imaging (eg. FDG-PET)	IFN y signature
	Inflammatory markers eg. IL6, CRP