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The effect of filaggrin deficiency on S. aureus skin colonization and virulence
| Effect of filaggrin deficiency | ||
|---|---|---|
| Primary outcomes | Secondary outcomes | Refs |
| Increased skin pH | Enhanced S. aureus growth and colonization | (58, 59) |
| Impaired skin barrier | Enhanced S. aureus migration through the epidermal barrier and into dermis | (43) |
| Increased density of sphingomyelin lipids in keratinocyte membranes | Enhanced binding of alpha-haemolysin (cytotoxic S. aureus virulence factor) | (67) |
