Figure 23.

PARP14 macrodomain-2 (MD2) inhibitors developed by Knapp et al. (in the green and pink boxes)^165,168 and Ekblad et al. (in the blue box)¹⁶⁶ along with the their inhibitory activity against MD2 and their selectivity. Crystal structure (PDB ID 5O2D) shows the binding mode of 82.