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. 2022 May 24;65(11):7532–7560. doi: 10.1021/acs.jmedchem.2c00281

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© 2022 The Authors. Published by American Chemical Society

Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).

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Binding modes of compounds 31 (A) and 32 (B, conformer 1; C, conformer 2) bound to PARP14 (PDB IDs 4F1Q and 4F1L). Residues are numbered according to isoform 1 of PARP14 (UniProt Q460N5-1), and this numbering has been used in all of the PARP14 crystal structures presented in the review.