Figure 8.

2-Aminobenzothiazole-4-carboxamides synthesized by Zhang et al.¹¹⁵ along with PARP14 IC₅₀ values; crystal structure of compound 42 in complex with PARP14 catalytic domain as observed in monomer B in the asymmetric unit (PDB ID 4PY4). It is important to note that the amide group of 42 was flipped because it was incorrect in the deposited model and resulted in clashes, and shown in the figure is the corrected model. Error in the original model also pushed the compound out from the very poor density observed in monomer A that was used by the authors to analyze the interaction.