. 2022 May 25;65(11):7729–7745. doi: 10.1021/acs.jmedchem.2c00076

Table 1. Initial SAR of 8-OHQ Derivatives Obtained from the NCI DTP Drug Repository Listed by Their NSC Codes (Commercially Available Compound 5 Is Included as a Structural Counterpart to 1)^a.

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Data represent mean values with standard deviation obtained from 2 to 53 independent PrestoBlue assays for MES-SA and MES-SA/Dx5 cells in the absence and presence (values in parentheses) of 1 μM of the P-gp inhibitor tariquidar (TQ). MDR-selectivity ratio (SR) is defined as the fraction of IC₅₀ values obtained in P-gp negative vs positive cells. See Table S1 for toxicity data on further MDR cell lines.

Table 1. Initial SAR of 8-OHQ Derivatives Obtained from the NCI DTP Drug Repository Listed by Their NSC Codes (Commercially Available Compound 5 Is Included as a Structural Counterpart to 1)a.

Table 1. Initial SAR of 8-OHQ Derivatives Obtained from the NCI DTP Drug Repository Listed by Their NSC Codes (Commercially Available Compound 5 Is Included as a Structural Counterpart to 1)^a.