. 2022 May 25;65(11):7729–7745. doi: 10.1021/acs.jmedchem.2c00076

Table 3. Further Derivatives with R5 Chloro-Substitution and Decorations of Pyrrolidine and Piperidine Rings in R7^a.

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Data represent mean IC₅₀ values with standard deviation obtained from 2 to 10 independent PrestoBlue assays for MES-SA and MES-SA/Dx5 cells in the absence and presence (values in parentheses) of 1 μM of the P-gp inhibitor TQ. MDR-selectivity ratio (SR) is defined as the fraction of IC₅₀ values obtained in P-gp negative vs positive cells.

Table 3. Further Derivatives with R5 Chloro-Substitution and Decorations of Pyrrolidine and Piperidine Rings in R7a.

Table 3. Further Derivatives with R5 Chloro-Substitution and Decorations of Pyrrolidine and Piperidine Rings in R7^a.