Table 4. Agar Dilution MICs (μg/mL) of Select NBTIs against N. gonorrhoeaea,b.
| compd | ATCC 49226 (WTc) | WHO G (GyrA S91F; ParE G410V) | WHO M (GyrA S91F, D95G) | WHO L (GyrA S91F, D95N; ParC D86N, S88P) |
|---|---|---|---|---|
| 1f | 0.25 | 1 | 0.5–1 | 1 to >1 |
| 4f | 0.12 | 0.25–0.5 | 0.12 | 0.5 |
| CIPd | 0.004–0.008 | 0.12 | 2 | >8 |
a
Determined in triplicate at Micromyx, LLC (Kalamazoo, MI) by agar dilution; ranges are shown where appropriate.
b
Mutations (if any) to type II topoisomerase enzymes are indicated in parentheses.33
c
WT = wild type.
d
CIP = ciprofloxacin.