TABLE 1.
Baseline Characteristics of Patients With Alcoholic Hepatitis From Whom Samples Were Obtained for Microdissection
| Characteristic | Severe AH (n = 6), Median (25–75 IQR) |
|---|---|
| Demographic data | |
| Age, median (IQR) | 54 (47–60) |
| Sex, male, n (%) | 3 (50) |
| Severity scores | |
| Child-Pugh, median (IQR) | 12 (11–13) |
| MELD, median (IQR) | 29 (27–31) |
| ABIC, median (IQR) | 7.9 (6.9–9.0) |
| HVPG, median (IQR) | nd |
| SIRS, n (%)* | |
| Decompensations, n (%) | |
| Ascites | 4 (67) |
| HE | 3(50) |
| UGIB | 4 (67) |
| AKI | 4 (67) |
| Infections | 5 (83) |
| Analytical parameters, median (IQR) | |
| Hemoglobin g/dL | 9.2 (9.2–11.3) |
| Leukocyte count ×109/L | 12.2 (8.3–20.5) |
| Platelet count ×109/L | 107 (83–120) |
| AST (IU/L) | 177 (146–201) |
| ALT (IU/L) | 58 (44–71) |
| Albumin (g/dL) | 2.4 (2.1–2.6) |
| Creatinine (mg/dL) | 0.8 (0.8–1.5) |
| Bilirubin (mg/dL) | 15.0 (11.0–22.9) |
| INR | 2.1 (1.9–2.3) |
| GGT (IU/L) | 367 (272–720) |
| ALP (IU/L) | 260 (233–304) |
| Sodium (mEq/L) | 129 (127–130) |
*
SIRS alone or SIRS plus infection.
Abbreviations: ABIC, age-bilirubin-INR-creatinine score; AH, alcoholic hepatitis; AKI, acute kidney injury; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transferase; HE, hepatic encephalopathy; HVPG, hepatic venous pressure gradient; INR, international normalized ratio; IQR, interquartile range; MELD, Model for End-Stage Liver Disease; SIRS, systemic inflammatory response syndrome; UGIB, upper gastrointestinal bleeding.