. Author manuscript; available in PMC: 2022 Jun 13.

Published in final edited form as: Hepatology. 2019 Mar 12;69(5):2180–2195. doi: 10.1002/hep.30472

TABLE 3.

Functional Analysis of Up-Regulated Genes in Cirrhotic Organoids Transcriptome

KEGG	P Value	IPA Pathways	P Value
Hippo signaling pathway	2.16E-06	Wnt/β-catenin signaling	7.76E-05
Tight junction	5.18E-06	ERK/MAPK signaling	8.51E-05
Apoptosis	1.56E-05	PI3K/AKT signaling	1.29E-04
TNF signaling pathway	7.98E-04	IL-8 signaling	1.51E-04
Leukocyte transendothelial migration	2.66E-3	Chemokine signaling	1.70E-04
ErbB signaling pathway	9.92E-3	Granulocyte adhesion and diapedesis	3.33E-2
Wnt signaling pathway	1.33E-2	NF-κB activation by viruses	3.55E-2
TGF-beta signaling pathway	4.71E-2

Abbreviations: ErbB, erythroblastic leukemia viral oncogene homolog; PI3K, phosphoinositide 3-kinase; TGF, transforming growth factor.