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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Nat Chem Biol. 2021 Nov 15;18(1):56–63. doi: 10.1038/s41589-021-00898-0

Extended Data Fig. 3 ∣. Selectivity profile.

Extended Data Fig. 3 ∣

Inhibitory activity of 1 and 10 μM (red and green resp.) UNC6934 (a) or UNC7145 (b) on a panel of 33 protein methyltransferases. Experiments run as three independent measurements. Constructs used for NSD1, NSD2 and NSD3 correspond to the catalytic domain (residues 1810-2120, 934-1241 and 1014-1323 respectively).