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. 2022 Jan 5;51(3):759–768. doi: 10.1093/ije/dyab270

Figure 3.

Figure 3

Pregnancy outcomes in relation to 18-week glycated haemoglobin (HbA1c) among up to 2874 singleton pregnancies, Norway, 2002–09. Panel A) Predicted risk of preterm birth. Panel B) Predicted risk of preeclampsia. Panel C) Predicted risk of any congenital malformation. Solid lines show the predicted values, with dashed lines showing the 95% confidence intervals. The predictions were made using a binomial regression model with restricted cubic splines for HbA1c with four knots (placed at 28, 32, 34 and 38 mmol/mol). Adjusted for maternal age (set to mean), body mass index (BMI) (set to mean), and smoking (set to non-smokers). Note that HbA1c levels were grouped at the extremes, with 42+ mmol/mol (6%) as the highest value (16 observations) and 24 mmol/mol (4.3%) as the lowest value (five observations).