Table 1.
Summary characteristics for each GWAS used to derive external weights in polygenic scores
| Phenotype | Author/consortium | Population | Sample size (cases) | Unit |
|---|---|---|---|---|
| Alcohol consumption | GWAS and Sequencing Consortium of Alcohol and Nicotine Use19 | European ancestry (summary statistics excluding UK Biobank) | 630 154 | Drinks per week |
| Body mass index | Genetic Investigation of Anthropometric Traits20 | European ancestry | 339 224 | SD (kg/m2) |
| Low-density lipoprotein cholesterol | Global Lipids Genetics consortium22 | European ancestry | 188 578 | SD (circulating lipids) |
| Smoking | Wootton et al.23 | White British (split sample GWAS of UK Biobank; see Supplementary Methods, available as Supplementary data at IJE online) | 318 147 | SD (lifetime smoking index) |
| Systolic blood pressure | Carter et al.18 | White British (split sample GWAS of UK Biobank; see Supplementary Methods, available as Supplementary data at IJE online) | 318 147 | SD (mm/Hg) |
| Atrial fibrillation | Roselli et al.24 | Predominantly European (84.2%) | 588 190 (65 446) | Log odds ratio |
| Coronary heart disease | CARDIoGRAMplusC4D6 | Predominantly European (77%) | 184 305 (60 801) | Log odds ratio |
| Type 2 diabetes | DIAbetes Genetics Replication And Meta-analysis21 | European ancestry | 159 208 (26 276) | Log odds ratio |
| Stroke | MEGASTROKE7 | Predominantly European (85%) | 521 612 (67 162) | Log odds ratio |
SD, standard deviation; GWAS, genome-wide association study.