Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 17;298(6):102040. doi: 10.1016/j.jbc.2022.102040

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

SaTrmK enzymatic activity with S. aureus tRNA^Leu.A, methylation of WT and mutant tRNA^Leu by SaTrmK. Each data point of the duplicate measurements is shown (pink and blue). The inset shows the dependence of SAH formed during the methylation of tRNA^Leu on SaTrmK concentration. B, inhibition of SaTrmK by sinefungin. The inset depicts the chemical structure of sinefungin. C, LC-MS analysis of SaTrmK-catalyzed methylation of tRNA^Leu. The panel labeled N¹-methyl-AMP refers to the commercial compound used as a standard. SaTrmK, S. aureus TrmK; TrmK, m1A22-tRNA methyltransferase.