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. 2022 May 17;298(6):102036. doi: 10.1016/j.jbc.2022.102036

Figure 7.

Figure 7

SGK1 inhibition exacerbates Porphyromonas gingivalis–infection induced alveolar bone loss in a mouse model.A, quantitative RT–PCR showing that SGK1 inhibition significantly enhances secretion of inflammatory cytokines in mice gingival tissue (n = 5). B, ELISA showing the levels of inflammatory cytokines in mouse serum. C, representative images of bone loss using methylene blue/eosin staining and quantified under microscope. D, quantification of alveolar bone loss represented by the distance from the CEJ to the ABC. Data are presented as the mean CEJ–ABC distance in millimeters ± SD (n = 5 mice per group). Error bars represent the SD. ∗p < 0.05, ∗∗∗p < 0.001. Data represent the arithmetic mean ± SD of three independent experiments. ABC, alveolar bone crest; CEJ, cementoenamel junction; SGK1, serum- and glucocorticoid-regulated kinase 1.