Table 2.

Hazard ratios for Overall Survival by DRSS^* stratum

	Derivation cohort		Tuning cohort		Geographic validation cohort
	HR (CI 95%)	p-value	HR (CI 95%)	p-value	HR (CI 95%)	p-value
Low	reference		reference		reference
Intermediate-1	1·26 (1·17, 1·36)	< 0·0001	1·25 (1·14, 1·37)	< 0·0001	1·48 (1·17, 1·88)	0·0011
Intermediate-2	1·53 (1·42, 1·66)	< 0·0001	1·52 (1·38, 1·67)	< 0·0001	1·62 (1·27, 2·08)	< 0·0001
High	2·03 (1·86, 2·22)	< 0·0001	2·04 (1·83, 2·28)	< 0·0001	2·61 (2·01, 3·39)	< 0·0001
Very High	2·87 (2·63, 3·13)	< 0·0001	2·90 (2·62, 3·22)	< 0·0001	3·70 (2·88, 4·74)	< 0·0001

^*The full multivariable results for OS, relapse incidence and non-relapse mortality are presented in appendix p. 5, 7–8

OS – overall survival; CI – confidence interval; HR – hazard ratio