Figure 5.

1-Ab^ΔIEC mice are more susceptible to infectious colitis. Infectious colitis was induced in I-Ab^WT (n = 7) and I-Ab^ΔIEC (n = 8) by oral administration of C rodentium and followed for 21 days. (A) Experimental design timeline. (B) Survival curve: 50% of the I-Ab^ΔIEC mice died by day 15 postinfection (p.i.). (C) Fecal lipocalin 2 concentration measured by ELISA in longitudinally collected samples (*P < .01, ***P < .001, Student t test). (D) Serum amyloid A concentration measured by ELISA in longitudinally collected blood samples. **P < .01, Student t test. (E) Representative hematoxylin-eosin (H&E)-stained sections of colons on day 9 p.i. (F) Violin plots of the colonic inflammation score assessed blindly in H&E stained sections (solid lines indicate medians and dashed lines indicate quartiles); *P < .05.