Table 4. Preliminary Pharmacokinetic Parameters of 37 CD-1 Mouse Plasma^a.

	37
route of administration	IVb	POc
dose (mg/kg)	0.5	2
AUCinf [μM h]	0.58	2.55
Cmax [μM]	0.58	0.58
Tmax [h]	n/a	1.00
T1/2 [h]	0.8	1.25
Vdss [L/kg]d	2.0	n/a
MRT [h]	1.01	3.01
Cl [mL/min/kg]	33.5	n/a
F [%]e		111%

^aData presented as mean values. Three animals per arm, three animals per time point.

^bDosed as a solution of the free base in 10% DMSO/90% 2-hydroxypropyl-beta-cyclodextrin (HPCD; 20% w/v).

^cDosed as a solution of the free base in DMSO: methylcellulose (0.5% w/v).

^dVolume of distribution (V_d) calculated with the steady-state method.

^eCalculation for F [%] is calculated relative to IV and assumes clearance does not change from that calculated for IV. Thus, calculated values >100 can arise where compound adsorption and/or elimination is dramatically different following PO versus IV.