Fig. 10.

Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of molecular pathways involved in the protection of fullerenol on the UVB exposed hCECs. A) KEGG pathway analysis for differently expressed mRNAs. Each node of the green circle represents a signaling pathway. Grey linear represents interactive relationships between two signaling pathways. Each node of the blue circle represents down-regulated genes and the red circle represents up-regulated genes. The red and oval boxes represent the pathways and genes that differ the most in this group. B-D) The relative mRNA expression of genes associated with the FoxO signaling pathway (B–D) or homologous recombination pathway (E-G) which were involved in the protection of fullerenol in the UVB irradiated hCECs screened by RNA-Seq. B) FOXO1 mRNA expression. C) PLK3 mRNA expression. D) PCK2 mRNA expression. E) TOP3A mRNA expression. F) TOP3B mRNA expression. G) POLD4 mRNA expression. N = 3 samples per group. Data were expressed as the mean ± SEM from three independent experiments. *P < 0.1, ****P < 0.0001 using one-way ANOVA and post-hoc Tukey's test. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)