Fig. 1.
δNfL (above vs. below median) and all-cause mortality by sex: Kaplan-Meier survival curve (a, b). a dNfL corresponds to empirical Bayes estimator for change in Loge-transformed plasma NfL over v1, v2, and/or v3 of HANDLS (δNfLbayes in Table 1). Below-median dNfL ranged between 0.0016891 and 0.0466214 with a mean ± SD of 0.0398147 ± 0.0055446; above-median dNfL ranged between 0.0466543 and 0.1086501, with a mean ± SD of 0.0559002 ± 0.0092975. Binary NfLv1 and δNfL (above vs. below or = median) based on the distributions in the final selected sample with a cutoff of 1.966279 for NfLv1 and 0.0466214 for δNfL. b Analyses were based on 401 women and 293 men selected at baseline of HANDLS with complete data on NfL exposures over 3 visits (see Method S1 for details). All-cause deaths through December 31, 2018: 20 deaths among women and 23 deaths among men. Analysis time is presented in years from v1 age