Table 7.

Trend of the wearing off periods after increase in the onabotulinumtoxinA dose. (n = 113)

	Wearing off period, days
36 weeks before the increase	16.11 ± 9.11
24 weeks before the increase	15.67 ± 11.08
12 weeks before the increase	16.54 ± 11.94
Day of increase to 200 Units	16.91 ± 10.36
12 weeks after the increase	14.00 ± 10.75 *
24 weeks after the increase	13.26 ± 9.13 **
36 weeks after the increase	14.68 ± 9.21 *

Data presented as mean ± SD; * P < 0.05, ** P < 0.01 for the paired t-test compared to the day of increase to 200 units