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. Author manuscript; available in PMC: 2022 Jun 13.
Published in final edited form as: Mol Pharm. 2009 May-Jun;6(3):790–800. doi: 10.1021/mp9000712

Table 1.

Binding Affinities of Radioimaging Agents to PSMA-Positive LNCaP in Culture and Calculated cLogP Values for PSMA-Targeted Radioimaging Agents

compound peptide spacer (X) cLogPa KD (nM)
3 none −3.94 176
4 NH-Glu-Phe-CO −3.45 60
5 NH-(CH2)8-Phe-Phe-CO −0.27 13.8 ± 3.9b
6 NH-(CH2)8-Phe-Glu-CO −2.11 31
7 NH-Phe-Glu-Ala-Phe-Phe-CO −4.64 102
8 NH-PEG6-Phe-CO −2.16 338
a

cLogP = calculated log (partition coefficient).

b

SD (n = 3).