Fig. 1.

Histology showing the complex and heterogeneous glomerular pathology in DKD. A: Minimal to mild glomerular pathology with mild mesangial expansion; Tervaert class I–IIa [20]. B: Severe mesangial expansion and hypercellularity; Tervaert class IIb. C: Ischaemic phenotype with collapse of glomerular segments, segmental sclerosis and mild mesangial expansion; Tervaert class IIa. D: Severe mesangial expansion, Kimmelstiel-Wilson nodule without mesangiolysis; Tervaert class III. E: Hyperfiltrating phenotype with enlarged glomerular tuft, perihilar capsular adhesion and severe mesangial expansion; Tervaert class IIb. F: Mild mesangial expansion, Kimmelstiel-Wilson nodule with mesangiolysis; Tervaert class III