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. 2022 Jun 13;23:208. doi: 10.1186/s12882-022-02794-8

Fig. 4.

Fig. 4

Determinants of glomerular filtration rate. Classic nephrology equation describing how GFR depends on the pressure across the filter and its coefficient of filtration, which is determined by its structural composition and surface area. In DKD, structural composition is impaired by loss of endothelial fenestration, injury and loss of podocytes and thickening of the glomerular basement membrane, and surface area is reduced by mesangial expansion due to fibrosis. ESRD End stage renal disease