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. 2022 Jun 13;29:39. doi: 10.1186/s12929-022-00825-y

Table 1.

In vitro experiments

Biological effects EMF Bio-system Field strength Exposure time References #
HSF1 activation 60 Hz

Human

HL60 cells

0.8µT, 80µT 20 min [6]
Mitochondrial activity 50 Hz

Human

SH-SY5Y

100-μT 24 h [7]
ROS production 900 MHz Rat astroglia 10 V/m 5, 10, 20 min [8]
Blastogenesis 3 Hz Human lymphocytes 60 G 72 h [9]
45Ca incorporation 30 Hz Human lymphocytes 0.15 mT [10]
Channel-activity 42.25 GHz Kidney cells

2 mW/cm2

continuous

20–30 min [11]
Voltage‐gated calcium ELF and Microwave Human and animal cells Pulsed and continuous Seconds to min [12]
Growth-related 60 Hz Human lymphoma

10 mV/cm

continuous

1 h [13]
RNA synthesis 60 Hz HL-60 cells 5.7 µT continuous 20 min [14]
DNA synthesis 15 Hz to 4 kHz Human fibroblasts 0.023–5.6 G, sinusoidal 1,2,24 h [15]
DNA synthesis 75 Hz Human chondrocytes

2.3 mT

pulsed

6 to 30 h [16]
Expression of microRNA 75 Hz Mononuclear cell from AD

3 mT

pulsed

15, 30, 60 min [17]
Expression of microRNA 50 Hz Mouse GC–2 cells

1 mT, 2 mT and 3 mT

pulsed

72 h (5 min on/10 min off) [18]
reduction of oxidative stress 75 Hz

Human

SH-SY5Y

2 mT

pulsed

10 min, 4 times a week [19]
reduction of oxidative stress 60 Hz

Human

SH-SY5Y

4 to 10 mT

continuous

20 min [20]
expression of hsp70 60 Hz Human breast cells 3 mT continuous 1 to 3 h [21]
Cytoprotection 60 Hz Rodent cardiomyocytes 8μT 30 min [22]
Ubiquitin–proteasome system 50 Hz Caco 2 cells 1 mT 24–72 h [23]
Ubiquitin–proteasome system 1.95 MHz KB cells 3 mW/g 1, 2, 3 h [24]
Ubiquitin–proteasome system 100 mT Rat hippocampal cells

100 mT

continuous

15 min [25]
Autophagy-lysosome systems 75 Hz SH-SY5Y cells

2 mT

pulsed

1 h [26]
Inflammation 27.12 MHz Human dermal fibroblasts

591 V/m

pulsed

30 min [27]
Cellular senescence 50 MHz Mouse fibroblasts 0.5 W/Kg continuous 30 min/d
β-amyloid (Aβ) deposition 64 MHz Human neurons 0.4-to 0.9 continuous 1 h/d × 21 days