Pharmacokinetics of peposertib following intravenous administration in FVB wild-type, Bcrp-knockout, P-gp-knockout, and triple-knockout mice. (A) Plasma concentration-time profile, (B) brain concentration-time profile, (C) Spinal cord concentration-time profile, (D) brain-to-plasma concentration ratios, and (E) spinal cord–to-plasma concentration ratios following a single intravenous bolus dose of 10 mg/kg in FVB wild-type, Bcrp-knockout, P-gp-knockout, and triple-knockout mice. Data represent mean ± S.D., n = 4.