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Pharmacokinetics of peposertib following oral administration in FVB wild-type and triple-knockout mice. Plasma, brain, and spinal cord concentration-time profiles following a single oral dose of 20 mg/kg in (A) wild-type and (B) triple-knockout mice. (C) Brain-to-plasma concentration ratios and (D) spinal cord–to-plasma concentration ratios following a single oral dose of 20 mg/kg in FVB wild-type and triple-knockout mice. Data represent mean ± S.D., n = 4.
